Sir Henry Oxenden, 1st Baronet (1614–1686) was an English politician who sat in the House of Commons at various times between 1645 and 1660.
Oxenden was the eldest son of Sir James Oxenden of Deane and his wife Margaret Nevinson, daughter of Thomas Nevinson of Eastry, Kent.
He was knighted on 11 July 1660, despite his family's rather dubious record of loyalty to the Crown.
Oxenden married firstly Mary Baker daughter of Robert Baker of St Martin in the Fields, by whom he had a daughter, and secondly, Elizabeth Meredith (died 1659) daughter of Sir William Meredith, 1st Baronet of Leeds Abbey, Kent and his first wife Susannah Barker.
They had issue James and Henry who successively succeeded to the baronetcy, and George, and several daughters including Susannah, who married Sir Robert Booth, Lord Chief Justice of Ireland, by whom she had four daughters.