Sir James Oxenden, 2nd Baronet (4 April 1641 – 29 September 1708), of Dene, Kent was an English politician who sat in the House of Commons between 1679 and 1702.
Oxenden was the son of Sir Henry Oxenden, 1st Baronet and his second wife Elizabeth Meredith, daughter of Sir William Meredith of Leeds Abbey, Kent.
Oxenden married firstly Elizabeth Chute, daughter of Edward Chute of Bethersden, and secondly, Arabella Watson sister of Lewis Earl of Rockingham.
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