Sir John Cole, 1st Baronet (died 1691) was an Anglo-Irish politician.
William was a Londoner, the only son of Emmanuel Cole, from a family which originated in Devon.
Sir John Cole was a Royalist who, as Governor of Enniskillen, had been a prominent promoter of the interests of Charles II of England.
On 23 January 1661, he was made a baronet of Newland in the Baronetage of Ireland in recognition of his loyalty to the Crown.
Sir John Cole was one of the commissioners appointed to implement the Act of Settlement 1662 in Ireland.