He succeeded to the considerable property of his grandfather Patrick Blake of St. Kitts in 1745 but later was left only a shilling by his father.
[2] In 1768, Blake was returned in a contest as Member of Parliament for Sudbury.
He was defeated at the 1774 general election but was returned for Sudbury on petition on 22 March 1775.
[2] In 1776, his wife Annabelle quit the marriage for France with George Boscawen and the Blakes became divorced in 1778.
[2] Through his daughter Annabella Blake, he was the grandfather of Henry John Adeane, Member (MP) of the Parliament of the United Kingdom for Cambridgeshire.