He was admitted to the Middle Temple on 19 July 1628, was knighted on 3 October 1629, and sat in the Parliament of Ireland of 1634–35 as MP either for Tuam or Galway county.
This was a result of his activities in Galway early in the year, which included aiding the amassing of a military force to oppose the British garrison at Forthill, overlooking the town.
He and Sir Richard Blake of Ardfry were captured by the soldiers of Owen Roe O'Neill in June 1648 but were released unharmed.
He was one of the Galwegians who supported negotiations to secure aid from Charles IV, Duke of Lorraine, in 1651.
The current holder of the title is Sir Anthony Teilo Bruce Blake, 18th Baronet, born in 1951.