It is located in Bangkok on the west bank of the Chao Phraya River, adjacent to Siriraj Hospital and opposite Thammasat University (Tha Phra Chan Campus).

The Faculty of Medicine Siriraj Hospital, Mahidol University was transferred a piece of land adjacent to the Chao Phraya River from the State Railway of Thailand following the board resolutions since 2003 from the cabinet and State Railway of Thailand, and finally on 11 January 2010 with an area of 33 rai, 2 ngan, and 94 square wa (53,976 square meters).

King Bhumibol Adulyadej graciously conferred Princess Sirindhorn to lay the foundation stone for the building part of the project 'Siriraj towards a top medical institute in Southeast Asia' around the old Bangkok Noi railway station and named the building 'Piyamaharajkarun Building'.

On 6 July 2010, the Faculty of Medicine board renamed the building as 'Siriraj Piyamaharajkarun Hospital (SiPH)'.

[2] Siriraj Piyamaharajkarun operates the following special medical centers:[3]