Following his tenure as lead performer of the R&B group Dru Hill, he quickly reached success as a solo act with the release of his debut studio album Unleash the Dragon (1999), which peaked at number two on the Billboard 200.

As a teen, Andrews worked at The Fudgery[5] in Harborplace at Baltimore's Inner Harbor with Larry "Jazz" Anthony, James "Woody" Green, and Tamir "Nokio" Ruffin.

Sisqó's solo debut, Unleash the Dragon, was released on Def Soul Records in November 1999.

Unleash the Dragon sold moderately at first, until the February 2000 release of its second single, the novelty "Thong Song".

During this period, Sisqó branched out into hosting the dance competition program Sisqós Shakedown on MTV, and into film, taking on supporting roles in the films Get Over It (2001) with Kirsten Dunst and Snow Dogs (2002) with Cuba Gooding, Jr.

"[8][9][10] In 2010, Sisqó was a contestant on the British reality television show Celebrity Big Brother 7, which he placed 8th.

The group also appeared at this time in the reality show Keith Sweat's Platinum House on BET's sister station Centric.

He resides in Maple Grove, Minnesota, with his wife Elizabeth Pham, with whom he has been romantically involved since 2003.