It changed locations a number of times until a permanent hospital campus was completed in 1894 by the German architect Kuno Waidmann, on the site of the former Villa Socias and a neighbouring graveyard in Vinogradska Street.

As of 2022[update], the hospital consists of 17 clinics and 7 specialized institutes, with a total of 853 beds and 2,334 employees in one campus.

Many of its buildings were built before World War 2 and lack modern facilities offered by newer similarly sized hospitals.

Current central campus consist of about a dozen disjointed buildings erected on an ad-hock basis without serious consideration for long term planning or access to facilities by ever growing population, the complex itself being around 50,000 m2.

Due to the 2020 Zagreb earthquake, and to a lesser extent the 2020 Petrinja earthquake, which damaged the central hospital complex, the Health Ministry proposed a plan to expand and modernise the central campus dramatically by demolishing older structures and in their place building modern, energy sustainable buildings.