[1] Sisto, son of Menapace, was born in Como to the important family Vicedomini originating from Cosio in Valtellina.
Sisto was the fourth son,[2] his elder brother, Pietrantonio, after a long political career became Vicegerent of Rome.
Sisto entered young in the Dominican Order, where he studied till to pass successfully a public disputation in Bologna in 1564.
[7] Sisto was an introverted and shy person, and he spent a lot of time in the village of Fiumalbo, in the mountains above Modena.
[4] Sisto Visdomini died in Modena on 27 September 1590 and he was buried in front of the main altar of the local church of San Domenico.