[1] In advanced cases, skeletal fluorosis causes painful damage to bones and joints.

Due to a high fluoride concentration in the body, the bone is hardened and thus less elastic, resulting in an increased frequency of fractures.

[3] Most patients with skeletal fluorosis show side effects from the high fluoride dose such as ruptures of the stomach lining and nausea.

The clinical symptoms of fluoride toxicity in the bones are indistinguishable from arthritis.

Even low level exposure to fluoride can cause or worsen the symptoms in consumers with vulnerable genotypes.

[8]) In India, especially the Nalgonda region (Telangana), a common cause of fluorosis is fluoride-rich drinking water that is sourced from deep-bore wells.

If fluorine intake is stopped, the amount in bone will decrease and be excreted via urine.