Distal expansion of the long bones as well as painful, swollen joints[3] and synovial villous proliferation are often seen.

[citation needed] Thought to be due to fibrovascular proliferation caused by accumulation of megakaryocytes in the digital vessels which are normally filtered by the lungs.

[citation needed] People with hypertrophic osteoarthropathy may have bone scans showing parallel lines of activity along the cortex of the shafts and ends of tibiae, femurs and radii; especially around the knees, ankles and wrists.

Treatment of lung cancer or other causes of hypertrophic osteoarthropathy results in regression of symptoms for some patients.

[citation needed] The eponymous 'Bamberger–Marie syndrome' is named for Austrian internist Eugen von Bamberger and French neurologist Pierre Marie.