In July 1881, Curly Bill Brocius attacked and killed about a dozen Mexican smugglers carrying silver and heading to the United States.
In retribution, the Mexican government attacked and killed Newman Haynes Clanton and others as they were driving cattle through Guadalupe Canyon.
In 1883, Apache Indians from Chihuahua's band surprised eight troopers of Troop D, Fourth Cavalry, killed three men, burned the wagons and supplies, and drove off forty horses and mules.
[1] Geronimo's final surrender to General Nelson A Miles on September 4, 1886, occurred at the western edge of this canyon.
As the surrender site is now on private property, commemorative monument has been erected to the northwest along SR 80, where it intersects with Skeleton Canyon Road in Arizona, at geographic coordinates 31°41′28″N 109°07′56″W / 31.69111°N 109.13222°W / 31.69111; -109.13222.