In the early 17th century, Skiffe's Creek bordered Martin's Hundred, a proprietary settlement dating to 1618 in the British Colony of Virginia.
Early speaker of the House of Burgesses Thomas Harwood established the Queen Hith plantation on both sides of Skiffe's Creek, and his descendants for generations kept it as their family seat, until great-great-grandson William Harwood finished Endview Plantation in 1769, and moved his family there.
Collis P. Huntington led the development of the Chesapeake and Ohio Railway through the new Church Hill Tunnel and down the Virginia Peninsula through Williamsburg where it finally reached coal piers located on the harbor Hampton Roads, the East Coast of the United States' largest ice-free port.
[1] The regional water system, which initially included an impingement of the Warwick River in western Warwick County, was begun as a project of Collis P. Huntington as part of the development of the lower peninsula with the Chesapeake and Ohio Railway, the coal piers on the harbor of Hampton Roads, and a massive shipyard which were the major sources of industrial growth which helped establish Newport News as an independent city in 1896.
Additionally, a small portion of the expansive Naval Weapons Station Yorktown is in the Skiffe's Creek watershed.