The Skipanon River is a tributary of the Columbia River, approximately 7 miles (11 km) long, on the Pacific coast of northwest Oregon in the United States.

It is the last tributary of the Columbia on the Oregon side, draining an area of coastal bottom land bordered by sand dunes and entering the river from the south at its mouth west of Astoria.

The Skipanon River issues from Cullaby Lake in western Clatsop County, northeast of Seaside and less than 3 miles (4.8 km) from the ocean.

It enters the northwest end of Youngs Bay at the mouth of the Columbia approximately 1 mile (1.6 km) northeast of Warrenton.

The charts of the Lewis and Clark Expedition show the stream as Skipanarwin Creek.