The facility has its origins in the Skipton Cottage Hospital in Granville Street which was built to commemorate the Golden Jubilee of Queen Victoria and which opened by the pioneer of women's education, Lucy Cavendish, in 1899.

[1] An annual gala was subsequently held to raise funds for equipment for the hospital.

[2] After the cottage hospital became too small for local healthcare demands, it was decided to acquire Whinfield House, the former home of Thomas Dewhurst, a mill owner.

[1] After the hospital joined the National Health Service in 1948, Princess Mary returned to open a new outpatients department in 1961.

[4] Blood testing returned to Skipton General Hospital in July 2021 after being relocated to alternative premises some 9 months previously during the COVID-19 crisis.