It serves local destinations, from its operations base at Modibo Keita International Airport, near Bamako, the Malian capital city.

It received an Air Operator Certificate, from the National Aviation Agency of Mali, on 22 July 2020.

With backing of the Al Sayegh Group of Abu Dhabi, Sky Mali was established and began commercial operations during the second half of 2020.

As of February 2021, five Malian destinations are served, including the airline's hub at Bamako International Airport.

[1][4] At its inception, Sky Mali SA, "a public limited company incorporated under Malian law", was a 100 percent subsidiary of Al Sayegh Group, an Emirati investment holding company, based in Abu Dhabi.