Stone was born in St. Louis, Missouri and moved to Kalamazoo, Michigan with his family at the age of 14.
His first movie role was in The Rules of Attraction, playing a speed freak named Quinlivan in a scene that ended up cut from the film.
He played Scarlett Johansson's character's husband in the flashback scenes for The Island,[7] and a cook in Waiting....[8] Stone was cast in Christopher Guest's For Your Consideration[9] as a trashy radio morning show host after Guest saw the "Cancun Coma" episode of Con.
In July 2007, Stone was cast in the comedy House Broken,[10] as Danny DeVito's son.
Stone is a regular at the Laugh Factory, The Improv, and The Comedy Store, in Hollywood, California.