Skyline High School is a public high school in the eastern part of Mesa, Arizona.

Skyline opened in 1999 and houses students in grades 9–12.

Skyline High School is a four-year, public, comprehensive high school with an estimated enrollment of 2,400 students.

The school is accredited by the North Central Association.

During the 2020-2021 school year, the demographic break of the 2,389 students enrolled was: [2] [3] vs. Perry (W) 43–41 at Desert Vista (L) 63–44 vs. Marcos de Niza (L) 38–3 vs. Hamilton (L) 21–14 vs. Mesa (W) 30–7 vs. Marcos de Niza (L) 44–37 Awards:[4]