Skywise was a South African domestic low-cost airline headquartered in Johannesburg and based at OR Tambo International Airport.

Skywise received its air service license in 2014, and the official launch flight took place on 11 February 2015.

On 20 October 2015, Skywise announced the reduction of frequency between Johannesburg and Cape Town from eight to six return flights per day.

Skywise was barred from taking off from Cape Town or Johannesburg for several hours on 11, 12 and 13 October 2015 because of debts owed to Airports Company South Africa (ACSA) and Air Traffic & Navigation Services (ATNS).

However, the airline later confirmed it had received a notice from Acsa warning it would be shut down because of unpaid airport charges[3] and by 10 November 2015 all of Skywise's aircraft had been withdrawn, effectively halting further operations.