[1] It operates one of the world's largest fleets of civil Lockheed L-100 Hercules cargo aircraft.

Safair assists aid and relief agencies such as the United Nations, World Food Programme, and the International Committee of the Red Cross in delivering much needed humanitarian aid to stricken regions on the African continent as well as other areas in the world where such assistance is required.

[5] Until 2018, Safair was contracted to the Italian Antarctic Program (National Antarctic Research Program (PNRA)) to support science over the austral summer, flying Lockheed L-100-30 missions from Christchurch, New Zealand to Zucchelli Station in Terra Nova Bay, Antarctica.

The initial plan to operate flights in October 2013 had to be cancelled, as a result of a High Court application by Comair.

[15] FlySafair operates passenger flights between Cape Town, George, PortElizabeth,Johannesburg, Lanseria, Durban, Bloemfontein, KMIA, East London, Zanzibar, Mauritius, Harare, Livingstone,Victoria Falls and Maputo.