Slayers Royal 2 retains its predecessor's overall gameplay of a tactical role-playing game with exploration phases, but with some differences.

Its other novelties include a new magic system that demands an uninterrupted invocation before being cast, taking a time proportional to the spell's power, and a necessity to keep the player's party well-fed for them to perform best in battle.

This task is made difficult though as Naga accompanied by the two imposters seeks to claim the treasure for herself and Alicia periodically appears to try to halt Lina's progress.

Along the way, Lina and Gourry once again meet with Zelgadis, Amelia, Sylphiel and Lark from the first Slayers Royal game all in a quest to uncover the truth behind the five towers of Rei Magnus.

Slayers Royal 2 was commercially successful, having remained on Japan's Sega Saturn top ten list five weeks after its release.