Slime City Massacre is a 2010 American science fiction comedy horror film directed by Greg Lamberson and starring Jennifer Bihl, Kealan Patrick Burke, Debbie Rochon and Robert Sabin.

It is a sequel to the 1988 film Slime City, also directed by Lamberson.Filmed at Central Terminal in Buffalo, NY.

A dirty bomb has decimated New York City's financial district and reduced midtown to a post-apocalyptic nightmare.

The neighborhood known as Slime City has been evacuated, except for the homeless, and in the ruins of a soup kitchen four squatters discover a supply of food that transforms them into hideous slimy creatures (like Zachary), driven to murder.

Meanwhile, a greedy developer who has set his sights on Slime City hires a team of mercenaries to wipe out the creatures.