In 1980 Rochon was cast as a punk-fan rock-concert extra in Ladies and Gentlemen, The Fabulous Stains after being alerted to an open-casting call by another homeless youth.

She garnered her first printed review in Backstage which read: "Debbie Rochon acquitted herself well as the cocaloony bird in Tennessee Williams' The Gnadiges Fraulein."

The Hubcap Awards founder Joe Bob Briggs crowned Rochon as runner-up Best Actress of the year in 1994 for her work on Abducted II: The Reunion.

In 2002, while working on an unreleased film in Tennessee, Rochon suffered an accident with a machete which resulted in the near-severing of the four fingers of her right hand.

In 2008, Rochon appeared in several new horror ventures, including the Michigan-made film Dog, Savaged, The Colour from the Dark, Psychosomatika, and Beg.

She can also be seen in the After Dark-released film Mulberry Street, directed by Jim Mickle, which had a theatrical run as part of the Horrorfest series in 2007.

Other celebrities include Tom Savini, Jim O'Rear, Brinke Stevens, Ken Foree, Stephen Susco, Joe Bob Briggs, James Gunn, and Mem Shannon.

By 2015, she had been nominated four times for the Rondo Hatton Classic Horror Award for her column "Diary of the Deb" in Fangoria magazine.

Breaking Glass Pictures released the feature film Dollface in September 2015, in which Rochon stars as a foul-mouthed groundskeeper.