Produced by Paul Brooks and Eric Newman, the film stars Nathan Fillion, Elizabeth Banks, Tania Saulnier, Gregg Henry, and Michael Rooker.

The parasite enters the town of Wheelsy, South Carolina, where it infects wealthy resident Grant by taking over his body and absorbing his mind.

During their search for Grant, a posse led by police chief Bill Pardy discovers Brenda, whose body has become inhumanly bloated from the larvae growing inside her.

The slug-like larvae burst from her body and infest everyone in town except Starla, Bill, Mayor Jack MacReady, and teenager Kylie Strutemyer.

Other members of Bill's posse are played by Tom Heaton as Tourneur, Ben Cotton as Charlie, and Dee Jay Jackson as Dwight.

Troma Films co-founder Lloyd Kaufman has a cameo as a drunk man and Rob Zombie provides the voice of Grant's physician Dr. Karl.

According to journalist Steve Palopoli: When the trailer for Slither came out, Internet boards about the movie suddenly lit up with protests from a legion of fans of the 1986 film Night of the Creeps.

Gunn has stated that both Cronenberg's Shivers and his 1979 film The Brood were the two biggest influences on the story in Slither, along with the 2000 manga Uzumaki by Junji Ito.

Also included are featurettes outlining how to make edible blood, and Lloyd Kaufman's documentary discussing his day on set, and the shooting of his one line (which was eventually cut from the film).

[12] In addition to new case artwork illustrated by artist Justin Osbourn, it includes new special features such as a new audio commentary with James Gunn and cast members, new interviews with James Gunn and actor Gregg Henry (Jack MacReady) as well as all of the special features found on the original DVD.

[13] Slither was a box office flop,[14] failing to recoup its production budget[15] following its debut in the United States and Canada on March 31, 2006, in 1,945 theaters.

[14] Universal distanced itself from Slither's poor box office performance, citing their distribution of the film as merely part of a deal with Gold Circle.

The site's critics consensus reads, "A slimy, B-movie homage oozing with affection for low-budget horror films, Slither is creepy and funny — if you've got the stomach for it.

[21] Guest critic Michael Phillips named Slither his DVD pick of the week on the television show Ebert & Roeper.

Slither picked up the 2006 Fangoria "Chainsaw Award" for Highest Body Count and garnered nominations in the categories Relationship From Hell, Dude You Don't Wanna Mess With, and Looks That Kill.