Smoaks is a town in Colleton County, South Carolina, United States.

Walterboro, the Colleton County seat, is 18 miles (29 km) to the southeast via US 21 and South Carolina Highway 64.

According to the United States Census Bureau, Smoaks has a total area of 1.6 square miles (4.2 km2), all land.

The racial makeup of the town was 85.71% White, 11.43% African American, and 2.86% from two or more races.

There were 13.3% of families and 15.9% of the population living below the poverty line, including 18.5% of under eighteens and 9.4% of those over 64.