Sneddon's syndrome may instead present with livedo racemosa, which involves larger, less organized patches of bluish-purple mottling of the skin.

Both are generally found first in the extremities, both worsen in cold and either may occur without Sneddon's syndrome or any other systemic disease.

[3] Sneddon's syndrome is a progressive, noninflammatory arteriopathy leading to the characteristic skin condition and to cerebrovascular problems, including stroke, transient ischemic attack (TIA), severe but transient neurological symptoms thought to be caused by cerebral vasospasm, coronary disease and early-onset dementia.

[citation needed] Sneddon's patients are generally treated with warfarin, maintaining a high INR of 3–4.

[1] Because most will experience significant relief of symptoms after several months of consistent INR in this range, treatment with warfarin is often used as a diagnostic tool.