In 2001, while reviewing the constitution of Guyana,[1] the National Assembly unanimously voted to amend it to outlaw discrimination based on sexual orientation.

Their first event was a forum held at the National Library during which SASOD lobbied members of parliament to pass the amendment to outlaw sexual orientation discrimination.

[9][10] In February 2009, Guyanese police arrested several transgender people for "wearing of female attire by men", which was illegal under Chapter 8:02 of the Laws of Guyana, section 153 (1) (xlvii) of the Summary Jurisdiction (Offences) Act.

[15] Additionally, SASOD and four of the former detainees filed a lawsuit in the High Court of Guyana challenging the constitutionality of the cross-dressing law.

[18][14] In response to the ruling, SASOD warned that Transgender citizens “will continue to be vulnerable to human rights abuses with this dubious decision.

"[23] Beginning in 2010, SASOD contributed to Guyana's Universal Periodic Review (UPR) by the United Nations Human Rights Council (UNHRC).

SASOD called for the elimination of laws that discriminate against same-sex relationships between consenting adults, as well as improving access to health care for LGBT persons.

In 2010, the Inter-Religious Organisation (IRO) of Guyana held a press conference to oppose the SASOD's annual film festival, Painting the Spectrum, on the grounds that it promotes "homosexual behavior" among youth.

[41][52] Later that year, 100 Christian leaders sponsored an advertisement opposing efforts led by SASOD to repeal laws against gay sex.