Inhibition of HDAC activity is estimated to affect the expression of only 2% of mammalian genes.

[3] In the lab, sodium butyrate is usually found as a white, water-soluble, crystalline solid.

[4] When working with sodium butyrate, gloves, eye protection and respiratory masks are advised for safety purposes.

[5] The compound is found in human diet, notably produced in large amounts from dietary fiber in the gut and present in Parmesan cheese and butter.

[6] Nevertheless, the most common source of sodium butyrate in the gut is from consumption of legumes.