Sodium trichloroacetate is a chemical compound with a formula of CCl3CO2Na.

It is used to increase sensitivity and precision during transcript mapping.

[1] It was previously used as an herbicide starting in the 1950s but regulators removed it from the market in the late 1980s and early 1990s.

However, it can easily be protonated in the presence of suitably strong acids: This reagent is useful for introducing the trichloromethyl group into other molecules.

Decarboxylation produces the trichloromethyl anion, which is a sufficiently strong nucleophile to attack various carbonyl functional groups, such as aldehydes, carboxylic acid anhydrides,[6] ketones (making a precursor for the Jocic–Reeve reaction), and acyl halides.