Sodium trifluoroacetate

Sodium trifluoroacetate is a chemical compound with a formula of CF3CO2Na.

[1] With a pKa of 0.23 for trifluoroacetic acid, the trifluoroacetate ion is an extremely weak base compared to acetic acid, which has a pKa of 4.76.

This is due to the electron-withdrawing effect of the three fluorine atoms adjacent the carboxylate group.

One convenient method is by dissolving an equivalent amount of sodium carbonate in 50% aqueous solution of trifluoroacetic acid.

The solution is filtered and evaporated by vacuum evaporation (with special care to avoid decomposition of the salt by overheating).

NFPA 704 four-colored diamond Health 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroform Flammability 0: Will not burn. E.g. water Instability 1: Normally stable, but can become unstable at elevated temperatures and pressures. E.g. calcium Special hazards (white): no code
The trifluoromethylation process with sodium trifluoroacetate.