Sodium zirconium cyclosilicate, sold under the brand name Lokelma, is a medication used to treat high blood potassium.

[11] A number of medications can also cause high blood potassium including spironolactone, NSAIDs, and angiotensin converting enzyme inhibitors.

[12] However, if hyperkalemia causes any ECG change it is considered a medical emergency[12] due to a risk of potentially fatal abnormal heart rhythms and is treated urgently.

[12] Other approved potassium binders in the United States include patiromer and sodium polystyrene sulfonate.

One viewpoint is that mild to moderate hyperkalemia is a secondary effect that denotes underlying medical problems.

[14] Accordingly, these problems are both proximate and ultimate causes of death,[14] In the United States, regulatory approval of ZS-9 was rejected by the Food and Drug Administration (FDA) in May 2016, due to issues associated with manufacturing.

(reference -zirconium silicate and zirconium germate molecular sieves and the process of using the same, US Patent 5,888,472) the recognition of the unique ion exchange properties and the potential use to remove toxins from the body were identified shortly thereafter ("process for removing toxins from bodily fluids using zirconium or titanium microporous compositions, US Patent 6,332,985).