Since September 2022, Papaioannou has been a producer and host of ERT 1 and ERTNEWS's 365 Moments, a Greek news magazine that covers an array of topics connected to politics, social issues, international affairs and history.
She is currently co-founder and CEO of ISTORIMA, the biggest oral history and story-telling project in Greece designed to benefit unemployed Greek youth.
She has worked at four major Greek television stations: Antenna, Mega, Skai, and Alpha, working in a variety of roles and capacities (journalist, editorial director, co-anchor, co-presenter, presenter, and producer), and has covered stories across the world as well as across Greece.
She served as head of the Foreign Press Office for the Athens 2004 Bid Committee for the Olympic Games.
[6] Papaioannou is the author of the book (in Greek), Hidden in the Aegean: A True Story, published in May 2011 by Patakis Editions.