Soi Dog's efforts include spaying and neutering to prevent unwanted litters, and providing rescue, vaccination, medical treatment, shelter, and adoption services for animals unable to return to the streets.

[4] It has received endorsement from international celebrities, including Judi Dench, Laura Carmichael, Peter Egan, and Ricky Gervais.

[7] Seeing the appalling situation in Thailand, American-born Margot Homburg Park decided to join hands with a British couple, John and Gill Dalley, to try and end the dogs' suffering.

[23] As of April 2024, they had neutered and vaccinated 1,177,730 dogs and cats, making their CNVR programme the largest of its kind in the world.

[24] The foundation provides research assistance to epidemiological studies of rabies,[25] parasitic (filarial) infections,[26] leptospirosis,[27] as well as drug (anaesthetic) effects.

[28] British celebrities Judi Dench, Laura Carmichael, Peter Egan, Penelope Wilton, and Ricky Gervais launched a public campaign to support the foundation in 2014.

[5] This proved a success in terms of political action: the National Assembly of Thailand passed its first animal welfare bill on 13 December 2014.

Although he was eliminated in the second round of MasterChef Celebrity Thailand, where he competed to win a one-million-baht prize for Soi Dog,[33][citation needed] Apart from the officials in the foundation, honorary ambassadors include Naomi Bromley, a British vegan campaigner; Dena Kaplan, an Australian actress, singer, and dancer;[34] Natalie Glebova, a Russian-Canadian model, writer, and holder of the Miss Universe 2005 title;[35] and Kyle Leask, an autistic boy, and his dog Miracle, winner of the Eukanuba Friends for Life award.

[37] In 2011, Gill Dalley was named the first Asia Pacific Canine hero for her work with Soi Dog Foundation.

[38] In 2014, the Soi Dog Foundation received the Thailand Green Excellence Award, conferred by Princess Ubol Ratana.

[40] In 2020, John Dalley was included in the Queen's Birthday Honours List and was awarded the Most Excellent Order of the British Empire for his work with the foundation.