Founded at the behest of King Chulalongkorn in 1889, the hospital initially occupied a five rai plot of land on one side of the Chao Phraya River.

The institution's original name was the "Hospital for the Mentally Ill" (Rong Phayaban Khon Sia Sati).

[3][4] In 1955, the hospital started to offer training programs in order to increase expertise in the field of psychiatry and mental health.

[5] The hospital was upgraded to the status of a division following a royal decree in 1974 to restructure the Department of Medical Services.

[2] Hospital director Dr. Sinngern Suksompong believes that greenery helps calm mental patients.