Classes offered include music, performing arts, journalism, TV and media production, ceramics, and computer applications.

There are vocational programs in health careers, childhood development, electrical work, carpentry, auto repair, advanced manufacturing, graphic communications, drafting, cosmetology, culinary arts, and metal fabrication.

Some of their most notable achievements are winning the 2023 NE District North Shore Event with their robot named Yoink, as well as back-to-back Team Spirit awards at both their competitions in 2023.

Somerville High School has a sports program, highlighted by the recent success of its Cross Country team, that went 6–0 in the Greater Boston League in 2007, 2008, 2009 and 2010, capturing the GBL championship each season.

Somerville High's outdoor track team also won the GBL Championships, with an undefeated winning streak for the 2008 through 2011 seasons.

Cherilus also excelled on Somerville's basketball and track teams, and was selected with the 17th overall pick in the 2008 NFL draft by the Detroit Lions.

In response to the COVID-19 pandemic, the 2020-2021 season was changed to feature a full-length play, multiple works written and/or directed by students, and a one-act musical.

On June 2, 2015, 59 Somerville High students attempted to break the world record for "most arm-linked people to stand up from the floor simultaneously."