A fifty-something husband, Gene Bergman (Wilder), and his wife, Annie (Hillary Bailey Smith), who is in her thirties, are learning to cope with raising 4-year-old fraternal twin sons, Sam and Gabe (Carl Michael Lindner and Ian Bottiglieri).
Gene ran an advertising agency with his partner, crabby best friend Jack Travis (Gregory Itzin), whose offices were located adjacent to both their homes.
Others seen were Annie's niece from another of her siblings, boy crazy teen Katy Mooney (Raegan Kotz), and Caleb (Cleavant Derricks), the neighborhood handyman.
The intended wit and charm of the show was drawn from Gene Wilder's comedic intuitiveness and the frantic mimicry and mugging he put on with his two young co-stars.
Jennifer Grey had originally won the role of Annie Bergman, and shot the first pilot; test audiences, however, disapproved of the age difference between her and Wilder.