Sondrio railway station is situated in Piazza Giovanni Bertacchi, at the southeastern edge of the town centre.

As a consequence of the nationalization of the Italian railways on 1 July 1905, the Valtellina line from Lecco and its rolling stock passed into the ownership of the FS.

The building containing the public conveniences, which was expanded in 2009, is now Milanese in style, with a green space in front of which there is a fountain with drinking water.

In front of the station, extending over the tracks, is the locomotive shed, which currently houses the historical resources of the rail heritage group ALe 883.

There is also a goods yard, no longer in use, and access to the pedestrian underpass, which links the passenger building with platforms 2 and 3, the bus station, the free municipal parking at the Policampus, the school campus and the districts beyond the railway.