[3][5][6] Sophia Akuffo worked in private practice and was appointed by Jerry Rawlings to the Supreme Court in November 1995.

She has been a member of the Governing Committee of the Commonwealth Judicial Education Institute,[3][7] and the chairperson of the Alternative Dispute Resolution Task Force for several years.

[1] On 11 May 2017, Akuffo was nominated as the highest ranking Judge of the Supreme Court of Ghana by Nana Akuffo-Addo, subject to approval by Parliament.

These included John Atta Mills who was her lecturer on Taxation at the Ghana Law School and also nominated her for the African Court of Human and Peoples’ Rights in Ethiopia.

[14][15][16] On 28 March 2020, Nana Akufo-Addo appointed Akuffo to chair a newly formed COVID-19 National Trust Fund inaugurated during the COVID-19 pandemic.