[4] After her husband's death in 1890 Sophia continued to give lectures on his work and hosted gatherings in her Athenian residence, the Iliou Melathron.

[citation needed] Sophia spent the rest of her life as a member of Athenian high society and sponsor of charitable endeavors.

In 1902, after witnessing the sufferings of Greek soldiers of the recent war with Turkey, she and a group of society ladies sponsored the construction of a sanatorium for tuberculosis patients in Goudi.

She was buried with state honors in the family tomb at the First Cemetery of Athens next to her husband, whom she outlived by 42 years.

In the 2007 German television film The Hunt for Troy [de], Sophia Engastromenou was portrayed by the French actress Mélanie Doutey.