Sophie Irene Loeb (July 4, 1876, Rivne, Volhynia, Russian Empire (now part of Ukraine) – January 18, 1929) was an American journalist and social-welfare advocate.
She was a school teacher in McKeesport, Pennsylvania, at the East End Public School before she married Ansel F. Loeb, in 1896.
In 1924, she became president of the Child Welfare Committee of America.
In 1927, she was invited to work with the social service section of the League of Nations in Geneva to frame an international code for the care of dependent and afflicted children.
The Sophie Irene Loeb Playground is in Chinatown, Manhattan.