Sophie Spitz (4 February 1910 – 11 August 1956) was an American pathologist who published the first case series of "juvenile melanoma," (a special form of benign melanocytic nevi), skin lesions that have come to be known as Spitz nevi.

[1][2] For her contributions to pathology, and especially for her foresight in advocating the use of the pap smear when it was newly devised, she is recognized as a prominent pathologist of her time.

[3] She earned her MD from Vanderbilt University in 1932 and commenced her residency at the New York Infirmary for Women and Children.

[6] Following World War II, she returned to work at the New York Infirmary and also at Memorial Sloan Kettering Cancer Center, where she described the twelve cases of what was then known as juvenile melanoma and recognized that these lesions have benign behavior despite their microscopic resemblance to melanoma.

This clinically important information came to be published in the American Journal of Pathology in 1948, and the lesion now bears her name.