The marriage was unhappy and the couple separated without ever taking divorce; Sophie lived in Italy while the duke served as the governor of Holland from 1811 to 1813.
Such was the sorrow of the Duchess that she had her daughter's body embalmed and returned to Athens where it was placed in a crypt under her temporary home on Peiraios Street.
A central fixture in the social life of Othonian Athens, the Duchess would host symposia on various topics of religion and politics in her palace.
Later in life, she commissioned Kleanthis to begin the construction of a final home and resting place for her beloved daughter's remains, the Castle of Rododafni.
After that, the Duchess withdrew from public life only agreeing to see her old friend, Fotini Mavromichali, lady-in-waiting for Queen consort Amalia of Oldenburg.