Sophie of Brandenburg-Ansbach (23 March 1535 in Ansbach – 22 February 1587 in Legnica) was a princess of Brandenburg-Ansbach and by marriage Duchess of Legnica.
Sophie was a daughter of the Margrave George of Brandenburg-Ansbach-Kulmbach (1484–1543) from his third marriage to Emilie of Saxony (1516–1591), daughter of the Duke Henry IV of Saxony.
The marriage served to consolidate Sophie's father's position as Duke in Silesia.
The marriage proved unhappy, which was also due to a significant irritability on Sophie's side.
[1] Sophie is not to be confused with her eponymous aunt (1485–1537), who was also Duchess of Legnica.