[1] She grew up surrounded by the natural history collection of her father's Philadelphia Museum, which included hundreds of mounted bird specimens.

[1][3]During the yellow fever epidemic that plagued Philadelphia during the late summer and fall of 1803,[4] Sellers and her father remained in the city and worked on renovations to the museum.

[4] During the 1803 outbreak, Sellers worked for several months, copying Latin binomials (following the Linnaean system), English, and French common names from a handwritten "Book Catalogue", which had been prepared in 1795–1797 by Palisot de Beauvois,[1] onto wooden frames, which were then attached to the glass cases containing the mounted birds.

[1][3]Shortly after Sellers completed her "Catalogue in frames," Charles printed a summary of the bird collection in a pamphlet entitled A Guide to the Philadelphia Museum (1804):There are now in this collection, perhaps all the birds belonging to the Middle, many of which likewise belong to the Northern and Southern States, and a considerable number from South America, Europe, Africa, Asia, New Holland, and the recently discovered islands of the South Seas.

She was buried in a family plot in New Jerusalem Burial Ground in Upper Darby, and her remains were later moved to West Laurel Hill Cemetery, Bala Cynwyd, Montgomery County, Pennsylvania, US.