Soriano (Spanish pronunciation: [soˈɾjano]) is a department of Uruguay.

In 1624, a Franciscan Mission established a reduction for the indigenous tribes of the area named Santo Domingo Soriano.

In spite of interruptions in its existence, it is considered the earliest populated centre of the actual Uruguay.

[citation needed] The first division of Uruguay in departments happened on 27 January 1816.

[citation needed] As of the census of 2011, Soriano Department had a population of 82,592 (40.853 male and 41.742 female) and 32,075 households.