South Africa competed at the 2020 Summer Paralympics in Tokyo, Japan, from 24 August to 5 September 2021.

The team of 34 athletes competing in seven sports was announced on 14 August 2021, the chef de mission was Leon Fleiser.

[2] Eighteen athletes, eleven men and seven women, represented South Africa in athletics:[2] Three South African cyclists, two men and one woman, competed in road cycling:[2] South Africa entered two equestrian competitors, both women, Philippa Johnson-Dwyer (Grade IV) and Cayla van der Walt (Grade V) for the individual dressage competition.

[2] Four South African swimmers, two men and two women, competed.

[2] South Africa entered four wheelchair tennis players, two men and two women.