The South African Medical Journal is a monthly peer-reviewed open-access medical journal which has been published in South Africa since 1884.

Daniel Ncayiyana was the journal's first black editor-in-chief.

In 1933, following the rise of the Nazi Party in Germany, a correspondent for the journal reported on the systematic oppression of Jewish medical professionals in Germany.

These actions included denial of graduations for Jewish medical students, employment bans, forced resignations, raids on a Jewish medical association, and violent attacks on individual doctors.

The report concluded that the actions of the Nazi regime likely had the tacit support of the German medical establishment and ended with the request that South African doctors protest the actions.