South Carolina Highway 296 (SC 296) is a 21.803-mile (35.089 km) east–west state highway coursing through central Greenville and Spartanburg counties in the northwestern part of the U.S. state of South Carolina.

The west terminus of SC 296 is at a junction with SC 14 in west-central Greenville County and proceeds in a generally east-northeast direction.

Shortly after the junction, the route merges with SC 146, but soon separates from SC 146 a short distance afterward.

SC 296 then crosses into Spartanburg County as it traverses the Enoree River, and then intersects with SC 101 before passing through Reidville.

Within the city, SC 296 junctions with U.S. Route 29 (US 29) where the highway officially ends.