South Carolina Highway 27 (SC 27) is a 19.511-mile (31.400 km) primary state highway in the U.S. state of South Carolina.

It serves to connect the town of Ridgeville with nearby highways.

SC 27 is a two-lane rural highway that connect the town of Ridgeville south to the unincorporated community of Givhans to its south and highways U.S. Route 78 (US 78), Interstate 26 (I-26), and US 176 to its north.

The predominant features along the route is farmland mixed with forest and swamps.

In 1940, it was rerouted north from Ridgeville to US 78 and then spur up to the Berkeley County line.