The highway connects Orangeburg with the Lone Star area, via Cameron.

It travels to the northeast and immediately passes Veterans Memorial Park.

On the southwestern corner of South Carolina State University is an intersection with US 21 Bus./US 601 (Magnolia Street).

The highway resumes a rural routing, including an intersection with SC 6, until it meets its northern terminus, an intersection with SC 267, near Lone Star.

South Carolina Highway 69 (SC 69) was a state highway that was established in either 1934 or 1935 on a path from what then was SC 4 in Orangeburg to a point to the east-northeast for about 5 miles (8.0 km).